Antagonistic Effects of Suramin Against the Venom of the Iranian Snake Echis carinatus in Mice

Document Type : Research Articles

Authors

1 Ferdowsi University of Mashhad

2 Razi Vaccine and Serum Research Institute

Abstract

Echis carinatus (Saw-scale viper) is one of the most venomous snakes in Asia and some
parts of the Africa with deadly hemotoxic venom. It has been reported that suramin, an antitrypansomiasis
drug, can inhibits the toxic effects of some snake venoms. This study was
conducted to evaluate the antagonistic effects of suramin against the venom of the Iranian
snake Echis carinatus.
Adult albino mice weighing 35±5g were divided into nine groups (A1, A2, B1, B2, B3, C1,
C2, D and E) of 6-10 mice. Groups A1 and A2 (protocol A), which received the venom at 7 and
13 mg/kg, succumbed after 169±32 min and 53±16 min, respectively. Groups B1, B2 and B3
(protocol B) were treated with different doses of suramin 15 min after injection of venom.
The results show that suramin significantly delayed time to death in groups B1, B2 and B3
compared with groups A1 and A2 (P

Keywords


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