Ultrastructural organization of endothelial cells of the cerebellar cortex capillaries of the domestic bull

Articles in Press

Document Type : Short communication

Authors

• Alexey V Prusakov ¹
• Vladimir S Ponamarev ²

¹ Federal State Budgetary Educational Institution of Higher Education “Saint Petersburg State University of Veterinary Medicine”, Saint Petersburg, Russia

² Federal State Budgetary Educational Institution of Higher Education "Saint Petersburg State University of Veterinary Medicine"

10.22067/ijvst.2025.88947.1399

Abstract

The goal of the study was to establish the features of the ultrastructural organization of endothelial cells in the cerebellar cortex capillaries of a domestic bull. The study of the ultrastructural organization of endotheliocytes in the cerebellar cortex capillaries of domestic bulls (Bos taurus) is of significant interest both for fundamental science and for applied aspects of veterinary medicine and neurobiology. Understanding the ultrastructural organization of capillary endothelial cells in the cerebellar cortex allows better understanding of the microcirculation and metabolism mechanisms in this important part of the brain. This, in turn, may contribute to the development of new methods for diagnostics and treatment. Tissue fragments from the cerebellar cortex of a domestic bull, prepared using standard methods, were studied using electron microscopy. When writing the work, the terminology was given in accordance with the International Histological Nomenclature. It has been established that the endotheliocytes of the cerebellar cortex capillaries of the domestic bull are the primary link to the blood-brain barrier. Forming the lumen of the capillary, they contact each other with tight junctions and lie on a continuous basal membrane. The continuity of the latter and the presence of tight junctions block the possibility of spontaneous transport of macromolecular compounds from the bloodstream to the brain tissue.

Keywords

• brain
• cerebellar cortex
• histohematic barriers
• blood-brain barrier
• homeostasis

Main Subjects

• Anatomy

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