Document Type : Research Article
Authors
1
Department of pathobiology, Faculty of veterinary medicine, University of Tabriz, Tabriz, Iran
2
Division of Epidemiology and Zoonoses, Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3
Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
4
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
10.22067/ijvst.2025.93963.1562
Abstract
Multiple sclerosis is a chronic autoimmune disease of the central nervous system, characterized by demyelination and neurodegeneration of the brain, spinal cord. Echinococcus granulosus the causative agent of Cystic echinococcosis induces host immunomodulation which protect it from the anti-parasitic immune response. Curcumin is a natural polyphenol component with proved anti-inflammatory and antioxidant properties. Current study was conducted to explore the immunomodulatory effects of Echinococcus granulosus protoscolices in experimental autoimmune encephalomyelitis as a model of multiple sclerosis in rats and to compare it with therapeutic effect of curcumin. 40 Sprague Dawley rats were randomly divided into four groups, include: normal control, experimental autoimmune encephalomyelitis group, experimental autoimmune encephalomyelitisrats treated with Echinococcus granulosus protoscolices and experimental autoimmune encephalomyelitisrats treated with curcumin. Proinflammatory cytokines, brain nitric oxide concentration, serum myeloperoxidase activity and serum malondialdehyde level was evaluated. Based on our results, experimental autoimmune encephalomyelitiscaused significant increase in proinflammatory cytokines, myeloperoxidase activity, malondialdehyde levels and nitric oxide concentration as compared with the control group. Treatment with curcumin and Echinococcus granulosus protoscolices reduced the release of inflammatory cytokines, myeloperoxidase activity, malondialdehyde levels and nitric oxide concentration compared to experimental autoimmune encephalomyelitis group. No difference was observed between curcumin and Echinococcus granulosus protoscolices treated groups. The results of current study showed that Echinococcus granulosus protoscolices confer a therapeutic effect on experimental autoimmune encephalomyelitis as a model of Multiple sclerosis by decreasing the production of pro-inflammatory cytokines and inhibiting oxidative stress.The similar role was observed for curcumin. The efficacy of Echinococcus granulosus protoscolices was equal to curcumin.
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