Identification of Effective Genes in Feline Infectious Peritonitis and Drug Repurposing Using Systems Biology Approach

Document Type : Short communication

Authors

1 Department of Veterinary Medicine, Faculty of Veterinary and Agricultural Science, Shabestar Branch, Islamic Azad University, Shabestar, Iran.

2 Department of Animal Science, Faculty of Agriculture, Tabriz Branch, Islamic Azad University, Tabriz, Iran.

3 Department of Biology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.

10.22067/ijvst.2024.82835.1270

Abstract

FIP is a systemic infectious disease of cats of coronavirus origin. The lack of clear signs of the presence of the virus before clinical form presentation, and the absence of easy and inexpensive diagnostic tests to confirm virus presence are among the problems for controlling and preventing the spread of the virus. In addition, there is not yet any approved medications or treatment protocols for this disease. In this paper, the gene co-expression  network was first reconstructed and modulated using the STRING database and Cytoscape software. The GO and pathways of the modules were obtained using the DAVID and KEGG databases. The most important possible pathways are proteasome, protein processing in the endoplasmic reticulum, protein export, aminoacyl-tRNA biosynthesis, phagosome, tuberculosis, and T cell receptor signaling pathway. In the other part of the study, the gene-drug network regeneration strategy was used to identify a potential medicine reconstructed using the DGIdb database and Cytoscape software using the drug-gene network. BORTEZOMIB, CARFILZOMIB, OPROZOMIB, IXAZOMIB CITRATE, MARIZOMIB, BCG VACCINE, IC14, NELFINAVIR, and RITONAVIR are some of our recommended drugs for this disease. Although our computational strategy predicts repurposable candidate drugs against FIP, more detailed experimental trials and clinical analyses of drug performance, toxicity, and validation are necessary to achieve an accurate and improved treatment protocol.
 

Keywords


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Volume 16, Issue 3 - Serial Number 36
This issue XML files are being prepared.
September 2024
Pages 99-108
  • Receive Date: 04 July 2023
  • Revise Date: 17 August 2024
  • Accept Date: 21 August 2024