Antidiabetic and protective effects of Ferula assa-foetida L. oleo gum resin ethanolic extract on the testis of streptozotocin-induced diabetic rats: a histopathological study

Articles in Press

Document Type : Research Article

Authors

• Zahra Asadollahi ¹
• Ahmad Ali Mohammadpour ²
• ebrahim latifi ³
• Hossein Nourani ⁴

¹ Basic science, Veterinary Medicine, Ferdowsi University, Mashhad, Iran

² Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

³ Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University, Mashhad, Iran

⁴ Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

10.22067/ijvst.2024.85138.1317

Abstract

Diabetes is one of the most common metabolic diseases worldwide which affects all organs, including the reproductive system. Today, many researchers use medicinal plants instead of chemical drugs to reduce their side effects. Ferula assa-foetida L. is one of the medicinal plants that have been used to treat many diseases traditionally for years. Present study has evaluated antidiabetic and protective effects of Ferula assa-foetida L. on the testis of streptozotocin-induced diabetic male rats. The study of histomorphology of diabetic rats treated with Ferula assa-foetida L. extract shows significant improvement of testes. Histological studies show that treatment with the Ferula assa-foetida L. extract significantly increases the number of sperm in the seminiferous tubules and reduces fibrosis. Our study confirms the improving effects of Ferula assa-foetida L. on histomorphometric and biochemical parameters in diabetes and testicular damage caused by it, which is partially attributed to the presence of bioactive compounds and antioxidants in Ferula assa-foetida L.

Keywords

• Ferula assa-foetida
• rat
• diabetes
• reproductive system
• spermatogenesis, medicinal plant

Main Subjects

• Histology

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