Ectopic migration of Fasciola sp. in the lung of a water buffalo (Bubalus bubalis)

Document Type : Case report


1 Tabriz Industrial Abattoir

2 Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

3 Department of Pathobiology, Faculty of Veterinary Medicine, Tabriz Islamic Azad University, Tabriz, Iran.

4 Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

5 Laboratory of Helminthology, Centro de Investigación en Enfermedades Tropicales, University of Costa Rica, San José, CostaRica.

6 Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran.


There are few reports of ectopic fasciolosis in the lungs of ruminants. Here, we report a rare case of ectopic pulmonary migration of Fasciola sp. in a water buffalo (Bubalus bubalis). In October 2021, during the routine veterinary inspection of the carcass and edible offal of a 3-year-old female buffalo in Tabriz industrial slaughterhouse, Iran, a severe liver infection with Fasciola parasites was observed. They were diagnosed as Fasciola hepatica based on size and gross morphology. One 3-cm fluke was recovered from the caudal lobe of the buffalo’s right lung. Histopathologically, chronic active pneumonia, along with mild interstitial fibrosis, alveolar septa and pleura thickening, and necrosis associated with severe mixed inflammatory cell infiltration was observed in the affected lung. This case was observed for the first time in over 15 years of buffalo carcass inspection in the study area, indicating that pulmonary fasciolosis is rare in Bubalus bubalis.


1.    Mas-Coma S, Bargues M, Valero M. Human fascioliasis infection sources, their diversity, incidence factors, analytical methods and prevention measures. Parasitology. 2018;145(13):1665-99. Doi: 10.1017/S0031182018000914.
2.    Calvani NED, Šlapeta J. Fasciola species introgression: just a fluke or something more? Trends Parasitol. 2021;37(1):25-34. Doi: 10.1016/
3.    Mas-Coma S, Agramunt VH, Valero MA. Neurological and ocular fascioliasis in humans. Adv Parasitol. 2014;84:27-149. Doi: 10.1016/B978-0-12-800099-1.00002-8.
4.    World Health Organization. Progress in assessment of morbidity due to Fasciola hepatica infection: a review of recent literature [Internet]. Schistosomiasis Control Unit. 1990.
5.    Torrel Pajares TS, Díaz Vásquez K, Rojas Moncada J, Coronado León JF, Aguilar Guevara CN, García Barjoveanu CT, et al. Fasciola hepatica ectópica en pulmón de bovinos sacrificados en el Centro de Beneficio Municipal de Cajamarca, Perú. Rev Investig Vet Perú. 2020;31(3). Doi: 10.15381/rivep.v31i3.18721.  
6.    Hussein M, Haroun E. Pulmonary fascioliasis in Sudanese cattle. Br Vet J. 1977;133(3):316-7. Doi: 10.1016/s0007-1935(17)34100-3.
7.    Moya F, Velázquez-Maldonado J. Forma errática de Fasciola hepatica en bovinos. Revista de Ciencias. 1983;5(1):27-30.
8.    Pillers AN. Fasciola hepatica Linnæus 1758 in the lungs of cattle. Vet J. 1930;86(5):172-5.Doi: 10.1016/S0372-5545(17)41066-2.
9.    Yoshihara S, Hung N, Hung N, Goto N. An erratic parasitism found in the lungs of sheep during experimental infection with Fasciola gigantica (Japanese strain). J Helminthol. 1998;72(3):227-30. Doi: 10.1017/s0022149x00016485.
10.    Hashemnia M, Rezaei F, Nikousefat Z, Ghashghaii A. Acute caprine fasciolosis: a case with unusual migration to lung. J Parasit Dis. 2015;39(3):514-7. Doi: 10.1007/s12639-013-0387-1.
11.    Keiser J, Utzinger J. Emerging foodborne trematodiasis. Emerg Infect Dis. 2005;11(10):1507–14. Doi: 10.3201/eid1110.050614.
12.    Rao M, Choudary C. An aberrant location of Fasciola gigantica in spleen and lung of Indian buffaloes (Bubalus bubalis) and pathological study. Indian Vet J. 1979;56(10):890-1.
13.    Dwivedi J, Singh C. The occurrence of Fasciola gigantica in the lungs of Indian buffaloes (Bos bubalis). Indian Vet J. 1965;42(9):662-3.
14.    Ministry of Agriculture, Annual production report [in Persian], Tehran, Iran, 2020.
15.    Haroun E, Hussein M. Clinico-pathological studies on naturally-occurring bovine fascioliasis in the Sudan. J Helminthol. 1975;49(3):143-52. Doi: 10.1017/s0022149x00023567.
16.    Boray JC. Experimental fascioliasis in Australia. Adv Parasitol. 1969;7:95-210. Doi: 10.1016/s0065-308x(08)60435-2.
  • Receive Date: 28 September 2022
  • Revise Date: 08 January 2023
  • Accept Date: 16 January 2023
  • First Publish Date: 21 January 2023