Rare case of hemangiopericytoma in a domestic short-haired cat

Document Type : Case report

Authors

1 Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad,Iran.

2 Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Iran

3 Department of Pathobiology, Faculty of veterinary medicine, Ferdowsi University of Mashhad, Mashhad,Iran.

4 Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

5 Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad,Mashhad, Iran

6 Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Abstract

    A two-year-old queen was referred to the surgery section of veterinary hospital with lateral recumbency position and the primary diagnosis of dystocia. The queen was highly lethargic and dehydrated, with a pale mucous membrane, a rectal temperature of 37.3 °C, and no vaginal discharge during first inspection. The primary examination revealed a big mass in the abdominal cavity, which was followed by other diagnostic investigations. Due to a huge and encroaching tumor and the patient's owner's refusal to accept any further therapies, the queen was euthanized during an exploratory celiotomy. This report describes a large Hemangiopericytoma (HPCy) in a domestic short-haired queen diagnosed based on physical examination, radiography, ultrasonography, histomorphology, and immunohistochemical reactivity. The results of pathology revealed a whorls around blood vessels and the "fingerprint" pattern of tumor with negative S-100 immunohistochemistry staining.   In dogs, HPCy is a common neoplasm, but it is a seldom finding in cats. There is no previous report of HPCy in the abdominal cavity as observed in the presented case to the authors' knowledge.

Keywords


1. Maruo, Takuya, Takuo Shida, Yasuhiro Fukuyama, Yasunori Hino, Toru Yamada, and Hiroo Madarame. Evaluation of intraoperative radiation therapy for incompletely resected or recurrent canine hemangiopericytoma: seventeen cases. Int J Appl Res Vet M 10 2012: 132-136.
2. Handharyani E, Ochiai K, Kadosawa T, Kimura T, Umemura T. Canine hemangiopericytoma: an evaluation of metastatic potential. J Vet Diagn Invest. 1999;11(5):474-8.
3. Blutke A, Knebel J, Brühschwein A, Breuer W, Hermanns W. Hemangiopericytoma in a cat: a case report. Vet Med-Czech. 2012;57(5).
4. Silva EOd, Romero F, Green KT, Martins MIM, Bracarense APFRL. Hemangiopericytoma in a female dog with direct invasion of abdominal cavity and pulmonary metastasis. Cienc Rural. 2014;44(2):358-61.
5. Baldi A, Spugnini EP. Thoracic haemangiopericytoma in a cat. Vet Rec. 2006;159(18):598-600.
6. Perez J, Bautista MJ, Rollon E, Lara FCn-Md, Carrasco L, Mulas JMndl. Immunohistochemical characterization of hemangiopericytomas and other spindle cell tumors in the dog. Vet Pathol. 1996;33(4):391-7.
7. Richardson RC, Render JA, Rudd RG, Shupe RE, Carlton WW. Metastatic canine hemangiopericytoma. Javma-J Am Vet Med A. 1983;182(7):705-6.
8. Pantekoek J, Schiefer B. Metastasising canine fibrosarcoma originally diagnosed as haemangiopericytoma. J Small Anim Pract. 1975;16(12):259-65.
9. Postorino NC. Prognostic variables for canine hemangiopericytoma: 50 cases (1974-1984). J Am Anim Hosp Assoc. 1988;24:501-9.
10. Bostock DE, Dye MT. Prognosis after surgical excision of canine fibrous connective tissue sarcomas. Vet Pathol. 1980;17(5):581-8.
11. Schenck PA, Chew DJ, Nagode LA, Rosol TJ. Disorders of calcium: hypercalcemia and hypocalcemia. Fluid, electrolyte, and acid-base disorders in small animal practice. 2006;4:120-94.
12. Trojani M, Contesso G, Coindre JM, Rouesse J, Bui NB, De Mascarel A, et al. Soft tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system. Int J Cancer. 1984;33(1):37-42.
13. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Mesenchymal neoplasms and other tumors. Skin diseases of the dog and cat Clinical and Histopathologic Diagnosis 2nd ed, Blackwell Science, Oxford. 2005:722-7.
14. Nonaka D, Chiriboga L, Rubin BP. Differential expression of S100 protein subtypes in malignant melanoma, and benign and malignant peripheral nerve sheath tumors. J Cutan Pathol. 2008 Nov;35(11):1014-9.
15. Allen H. Hemangiopericytoma in the dog. 2003.
16. Graves GM, Bjorling DE, Mahaffey E. Canine hemangiopericytoma: 23 cases (1967-1984). Javma-J Am Vet Med A. 1988;192(1):99-102.