Premedication for intrathecal anesthesia in dogs: xylazine versus propofol

Document Type : Research Articles

Authors

1 Department of Surgery, Faculty of Veterinary Medicine, Dicle University, 21280, Diyarbakır, Turkey.

2 Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, 36300, Kars, Turkey.

3 Department of Biochemistry Faculty of Veterinary Medicine, Kafkas University, 36300, Kars, Turkey.

Abstract

This study aimed to compare the effects of xylazine or propofol before intrathecal (IT) bupivacaine administration in dogs. The study was conducted in two groups of 10 dogs each. In group I (XG), intrathecal injection of 20 mg bupivacaine was administered into the subarachnoid space in the lumbosacral area after treatment with 1 mg/kg intravenous (iv) xylazine. In group II (PG), 4 mg/kg iv propofol was administered before IT bupivacaine administration. The onset, duration, and magnitude of sensory block (scale 0–3) were determined using the pin-prick test throughout the anesthesia. Duration of surgery (XG: 47.20 ± 5.01 min, PG: 50.85 ± 6.97 min) and duration of anesthesia (XG: 92.20 ± 7.02 min, PG: 94.50 ± 7.26 min) were not significantly different between the groups. This study concludes that propofol administration before IT anesthesia with bupivacaine maintains safe levels of IT anesthesia and can therefore be used as an alternative to xylazine treatment.

Keywords


    Yayla S, Kilic E. The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. Kafkas Univ Vet Fak Derg. 2010; 16: 835-840.
2.    Yayla S, Kilic E, Aksoy O, Ozaydin I, Ogun M, Steagall PVM. The effects of subarachnoid administration of hyperbaric solutions of bupivacaine or ropivacaine in xylazine-sedated calves undergoing surgery. Vet Rec. 2013; 173: 580+.
3.    Ozaydin I, Kilic E. Lumbosacral intrathecal anaesthesia with isobaric bupivacaine in cattle. Indian Vet J. 2003; 80: 540-542.
4.    Kacar C, Ozaydin I, Oral H, Kilic E, Gurbulak K, Aksoy O. Intrathecal slow infusion of isobaric bupivacaine HCl in low-dose for ovariohysterectomy in dogs. Bull Vet Inst Pulawy. 2007; 51: 89-92.
5.    Luck JF, Fettes PDW, Wildsmith AW. Spinal anaesthesia for elective surgery: A comparison of hyperbaric solutions of racemic bupivacaine, levobupivacaine, and ropivacaine. Br J Anaesth. 2008; 101: 705-710.
6.    De Barros GAM, Marques MEA, Ganem EM. The effects of intrathecal administration of betamethasone over the dogs’ spinal cord and meninges. Acta Cir Bras. 2007; 22 (5): 361-365.
7.    Skarda R. Local and regional anesthetic and analgesic techniques in dogs. In, Thurman JC, Tranquilli WJ, Benson GJ (Eds): Lumb and Jones’ Veterinary Anesthesia, 3rd edn., 1996; p 434-447. Baltimore: Williams and Wilkins.
8.    Torske KE, Dyson DH. Epidural analgesia and anesthesia. Vet Clin North Am: Small Anim Pract. 2000; 30 (4): 859-874.
9.    Yayla S, Kacar C, Kilic E, Kaya S, Kuru M, Ermutlu CS, Ozaydın I, Huseyinoglu U, Ogun M. The effects of intrathecal administration of bupivacaine or ropivacaine following administration of propofol in dogs undergoing ovariohysterectomy. Kafkas Univ Vet Fak Derg. 2017; 23 (3): 363-367.
10.    Yayla S, Kacar C, Kaya D, Merhan O, Aksoy O, Kilic E, Kaya S. Clinical, biochemical and haemodynamic effects of the intrathecal ketamine for ovariohysterectomy in bitches. Bull Vet Ins Pulawy. 2012; 56: 299-303.
11.    Okumus Z, The effect of α2 adrenoceptor agonists and antogonists in dogs. Turkish J Vet Surg. 2003; 9(1-2): 68-73.
12.    Kamiloglu A, Kamiloglu NN, Ozturk S, Atalan G,  Kilic E. Clinical assessment of epidural analgesia induced by xylazine-lidocaine combination accompanied by xylazine sedation in calves. Irish Veterinary Journal. 2005; 58: 567-570.
13.    Ermutlu CS. Comparison of use of xylazine-ketamine or propofol on postoperative pain prior to sevoflurane-induced inhalation anesthesia in dogs. MAE Vet Fak Derg. 2018, 3(1): 43-54.
14.    Blue JT, Short CE. Preanesthetic evaluation and clinical pathology. In, Shot CE (Ed): Principles and Practice of Veterinary Anesthesia. 3-7, Williams & Wilkins, Baltimore. 1987.
15.    Kilic E, Yayla S, Kamiloglu A, Baran V, Ogun M. Effects of intrathecal administration of ketamine HCl in young calves: A clinical trial. Bull Vet Inst Pulawy. 2015; 59: 155-159.
16.    Schuszler L, Igna C, Sala A, Brudiu I, Sabau M, Dascalu R. Intraoperative analgesic effect of butarphanol for ovariohysterectomy in bitches: A dose titration study. Lucrari Ştiintifice Med Vet. 2009; 2: 160-163.