Pathological study of experimentally induced tick bitten (Argas persicus) in poultry skin

Document Type : Review Articles


1 Urmia University, Urmia, Iran

2 Urmia University

3 Faculty Of Veterinary Medicine

4 Group Of ‍Clinical Sciences


The fowl blood sucking tick "Argas persicus" is of great medical and veterinary importance in tropical and subtropical regions because of its role as the vector of certain parasitic bacterial and viral pathogens. In this study, the pathological changes of its bite on the poultry skin have been investigated. Twenty two (12 infested with adults and 10 infested with nymphs) Ross broilers (308) were infested with the tick on the skin of hock joints. Other side healthy legs were used as control. Samples were collected after 6, 24, 48 and 96 hours and 1 or 2 weeks. The skin samples were fixed at 10% buffered formalin and histological sections were prepared using routine Haematoxylin and Eosin staining method. The results showed subcutaneous oedema, massive infiltration of lymphocytes, extensive hemorrhage, feather follicle oedema. Necrosis and epidermal hyperplasia are the prominent lesions in this study. It is concluded that the chicken infestation with Argas persicus caused cutaneous and subcutaneous lesions. Therefore, it can be considered as a cause of economic loss.


Main Subjects

Abbas, HS; Muhammad, NK; Zafir, I and Muhammad, SS( 2004). Tick Infestation in Poultry. International Journal of Agriculture & Biology 6, 1162-1165.
Adamu, M; Troskie, M; Oshadu, DO; Malatji, DP; Penzhorn, BL and Matjila,PT(2014). Occurrence of ticktransmitted pathogensin dogs in Jos, Plateau State, Nigeria. Parasites & vectors 7, 119. Andrade, BB; Teixeira, CR; Barral, A and Barral-Netto, M( 2005). Haematophagous arthropod saliva and host defense system: a tale of tear and blood. Anais da Academia Brasileira de Ciencias 77, 65-69.
Arocha-Pinango, CL; Marchi, R; Carvaja,LZ and Guerrero, B(1999). Invertebrate compounds acting on the hemostatic mechanism. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 10, 43-68.
Bergman, DK; Palmer, MJ; Caimano, MJ; Radolf, JD and Wikel, SK(2000). Isolation and molecular cloning of a secreted immunosuppressant protein from Dermacentor andersoni salivary gland. The Journal of parasitology 86, 516-525.
Bowman, AS and Sauer, JR(2004). Tick salivary glands: function, physiology and future. Parasitology 129, S67-81. Cavassani, KA; Aliberti, JC; Dias, AR; Silva, JS and Ferreira, BR(2005). Tick saliva inhibits differentiation, maturation and function of murine bone-marrow-derived dendritic cells. Immunology 114, 235245.
Gholizadeh, M; Tavassoli, M; Rezaei, F and Nikousefat, Z(2015). Evaluation of histopathological features of Argas reflexus bite in pigeon. The Iranian Journal of Veterinary Science and Technology 6, 14 -20.
Hobbenaghi, R; Tavassoli, M; Alimehr, M; Shokrpoor, S and Ghorbanzadeghan, M(2012). Histopathological study of the mite biting (Dermanyssus gallinae) in poultry skin. Veterinary research forum 3, 205-208.
Hoffmann, A; Walsmann, P; Riesener, G;Paintz, M and Markwardt, F(1991). Isolation and characterization of a thrombin inhibitor from the tick ixodes ricinus. Die Pharmazie 46, 209-212.
Horn, F; dos Santos, PC and Termignoni, C (2000). Boophilus microplus anticoagulant protein: an antithrombin inhibitor isolated from the cattle tick saliva. Archives of biochemistry and biophysics 384, 68-73.
Iwanaga, S; Okada, M; Isawa, H; Morita, A; Yuda, M and Chinzei, Y( 2003). Identification and characterization of novel salivary thrombin inhibitors from the ixodidae tick, Haemaphysalis longicornis. European journal of biochemistry/ FEBS 270, 1926-1934.
James, F and Zachary, MDM(2012). Pathologic Basis of Veterinary Disease, 5th Edition. Penny Rudolph, United State, pp. 1340. Kubes, M; Fuchsberger, N; Labuda, M; Zuffova, E and Nuttall, PA(1994). Salivary gland extracts ofpartially fed Dermacentor reticulatus ticks decrease natural killer cell activity in vitro. Immunology 82, 113-116.
Motoyashiki, T; Tu, AT; Azimov, DA and Ibragim, K(2003). Isolation of anticoagulant from the venom of tick, Boophilus calcaratus, from Uzbekistan. Thrombosis research 110, 235-241.
Nienaber, J; Gaspar, AR and Neitz, AW(1999). Savignin, a potent thrombin inhibitor isolated from the salivary glands of the tick Ornithodoros savignyi (Acari: Argasidae). Experimental parasitology 93, 82-91.
Petrov, D and Gecheva, G(1975). Study of some biological peculiarities of Argas persicus. Veterinarno-meditsinski nauki 12, 25-32. Phulan, MS; Bhatti, WM andBuriro, SN(1984). Incidence of Argas (Persicargas) persicus in poultry.Pakistan veterinary journal 4, 174-175.
Ramachandra, RN and Wikel, SK(1992). Modulation of host-immune responses by ticks (Acari: Ixodidae): effect of salivary gland extracts on host macrophages and lymphocyte cytokine production. Journal of medical entomology 29, 818-826.
Ribeiro, JM and Francischetti,IM(2003). Role of arthropod saliva in blood feeding: sialome and post-sialome perspectives. Annual review of entomology 48, 73-88.
Ribeiro, JM and Mather, TN(1998). Ixodes scapularis: salivary kininase activity is a metallo dipeptidyl carboxypeptidase. Experimental parasitology 89, 213-221.
Ribeiro, JM; Weis, JJ and Telford, SR (1990). Saliva of the tick Ixodes dammini inhibits neutrophil function. Experimental parasitology 70, 382-388.
Rosenstein, M(1976). Paralysis in chickens caused by larvae of the poultrytick, Argas persicus. Avian diseases 20, 407409. Schoeler, GB and Wikel, SK(2001). Modulation of host immunity by haematophagous arthropods. Annals of tropical medicine and parasitology 95, 755-771.
Soliman, A; Mousa, SA; Gad, N; Desouky, U and Sokkar, IM(1988) .Rodents and ticks, as a reservoir of Mycoplasma in poultry farms. Assiut Veterinary Medical Journal 19, 183-189.
Srivastava, SC; Khan, MH and Moin, R(1981). Note on the biology of poultry tick,Argas persicus Oken Acarina: Argasidae. Indian Journal of Animal Sciences 51, 387-389.
Steen, NA; Barker, SC and Alewood, PF(2006). Proteins in the saliva of the Ixodida (ticks): pharmacological features and biological significance. Toxicon : official journal of the International Society on Toxinology 47, 1-20.
Stefanov, V; Matev, I and Balimezov, I(1975). Role of ticks of the species Argas persicus Oken, 1818, in the epizootology of pullorum disease in birds. Veterinarno-meditsinski nauki 12, 45-50.
Trager, W(1940). A Note on the Problem of acquired Immunity to Argasid Ticks. Journal of Parasitology 26, 71-74.
Wall, R and Sheare, D(1997). Veterinary Entomology. Chapman & Hall, London,pp. 96-149.
Wikel, SK and Alarcon-Chaidez, FJ(2001). Progress toward molecular characterization of ectoparasite modulation of host immunity. Veterinary parasitology 101, 275-287.
Zhu, K; Bowman, AS; Brigham, DL; Essenberg, RC; Dillwith, JW and Sauer, JR(1997). Isolation and characterization of americanin, a specific inhibitor of thrombin, from the salivary glands of the lone star tick Amblyomma americanum (L.). Experimental parasitology 87, 3038.