A Diarrhoeic Dog with Clinical and Histopathologic Signs of ICH (Infectious Canine Hepatitis)

Document Type : Research Articles

Authors

Shahid Chamran University of Ahvaz

Abstract

A 3-month-old male German shepherd dog was referred with depression, vomition, hemorrhagic diarrhea, abdominal pain, anorexia and dehydration. The affected dog did not have any history of vaccination. Despite treatment, the animal died within 2 days after the onset of clinical signs. Gross examination of tissues showed hemorrhages (ecchymoses) in the mucosa of the digestive tract. The liver was congested and slightly enlarged. The gall bladder wall was edematous. The spleen and lymph nodes were also edematous and congested. Light microscopic examination of tissues showed numerous large, basophilic intranuclear inclusion bodies within the hepatcytes and endothelial cells adjacent to the necrotic regions. A large area of hepatic necrosis, severe congestion of sinusoids accompanied by a mild mixed infiltration of inflammatory cells, were evident particularly in the periportal region. Fecal sample was examined for differential diagnosis of other viral, bacterial and parasitic diseases. Based on histopathological findings, Infectious canine Hepatitis (ICH) was suspected as the cause of death.

Keywords

Main Subjects


Boomkens, S.Y., Penning, L.C., Egberink,H.F., Van den Ingh, T.S. and Rothuizen, J.(2004) Hepatitis with special reference to
dogs. A review on the pathogenesis and infectious etiologies, including unpublished results of recent own studies.
Veterinary Quarterly 26, 107-114.
Caudell, D., Confer, A.W., Fulton, R.W.,Berry, A., Saliki, J.T., Fent, G.M. and Ritchey, J.W. (2005) Diagnosis of infectious canine hepatitis virus (CAV-1) infection in puppies with encephalopathy.Journal of Veterinary Diagnostic
Investigation 17, 58-61.
Chouinard, L., Martineau, D., Forget, C. and Girard, C. (1998) Use of polymerase chain reaction and immunohistochemistry for
detection of canine adenovirus type 1 in formalin-fixed, paraffin-embedded liver of dogs with chronic hepatitis or cirrhosis.
Journal of Veterinary Diagnostic Investigation 10, 320-325.
Decaro, N., Campolo, M., Elia, G.,Buonavoglia, D., Colaianni, M.L. Lorusso,A., Mari, V. and Buonavoglia, C. (2007) Infectious canine hepatitis: an "old" disease reemerging in Italy. Research in
Veterinary Science 83, 269-273.
Esfandiari, J. and Klingeborn, B. (2000) A comparative study of a new rapid and onestep test for the detection of parvovirus in
feces from dogs, cats and mink. Veterinary Medicine Journal, Series B 47, 145–153.
Greene, C.E. (2006) Infectious canine hepatitis and canine acidophil cell hepatitis. PP. 41-7. In: Greene, C.E. Infectious Diseases of the Dog and Cat. W.B. Saunders Co.
Philadelphia. Kobayashi, Y., Ochiai, K. and Itakura, C.(1993) Dual infection with canine distemper virus and infectious canine
hepatitis virus (canine adenovirus type 1) in a dog. Journal of Veterinary Medicine Science 55, 699-701.
Pratelli, A., Martella, V., Elia, G., Tempesta,M., Guarda, F., Capucchio, M.T.,Carmichael, L.E. and Buonavoglia, C.
(2001) Severe enteric disease in an animal shelter associated with dual infections by canine adenovirus type 1 and canine
coronavirus. Journal of Veterinary Medicine B. Infectious Disease and Veterinary Public Health 48, 385-392.
Sanchez-Cordon, P.J., Salguero, F.J., Nunez,A., Gomez-Villamandos, J.C. and Carrasco, L. (2002) Glomerulonephritis
associated with simultaneous canine adenovirus-1 and Dirofilaria immitis infection in a dog. Journal of Veterinary Medicine B. Infectious Disease and Veterinary Public Health 49, 235-239.
Sellon, R.K. (2005) Canine viral diseases. In:Ettinger, S.J. and Feldman, E.C.: Textbook of Veterinary Internal Medicine. W.B.
Saunders Co. Philadelphia. pp 646-52.
CAPTCHA Image