Comparison of sensory and motor blocking action of lidocaine and lidocaine-tramadol following brachial plexus block in sheep

Document Type : Research Articles

Authors

• Hadi Imani Rastabi
• Hadi Naddaf
• Ali Abbas Nikvand
• Mahnush Kamyabnia

Shahid Chamran University of Ahvaz

10.22067/veterinary.v2i10.73791

Abstract

The aim of the present study was to evaluate the effect of adding tramadol to lidocaine for brachial plexus block in sheep. Six healthy, adult ewes weighing 41.7 ± 3.82 kg were used. Using an electrical stimulator, brachial plexus block was performed with lidocaine (4 mg/kg) (LID), lidocaine (4 mg/kg)-tramadol (2 mg/kg) (LTL), and lidocaine (4 mg/kg)-tramadol (4 mg/kg) (LTH). All sheep received the three treatments with one-week interval. The final volume of administered solutions was adjusted to 0.3 mL/kg. Time to the onset and duration of anesthesia as well as changes in heart rate, respiratory rate, and rectal temperature were determined. Time to the onset of sensory blockade and motor blockade was not significantly different among groups. The duration of sensory blockade and motor blockade were significantly longer in LTH (128.3 ± 9.7 and 151.5 ± 21.5 min, respectively) compared with those of LID (88.6 ± 6.5 and 110.5 ± 21 min, respectively) and LTL (51.6 ± 11.8 and 89.6 ± 22.7 min, respectively). Although the onset of sensory blockade was longer than that of motor blockade in the three treatments, the difference was only significant in LTL. No significant differences were observed in heart rate, respiratory rate and rectal temperature among and within treatments. It was concluded that addition of tramadol (4 mg/kg) to lidocaine, without altering the onset, can provide more prolonged anesthesia than that of lidocaine in brachial plexus block in sheep.

Keywords

• Brachial plexus block
• Lidocaine
• Nerve stimulator
• Sheep
• Tramadol

20.1001.1.2008465.2018.10.2.4.8

Main Subjects

• Pharmacology

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References

1. Valverde A, Sinclair M. Ruminant and Swine Local Anesthetic

and Analgesic Techniques. In: Grimm KA, Lamont LA, Tranquilli

WJ, Greene SA, Robertson SA, editors. Veterinary Anesthesia

and Analgesia, The Fifth Edition of Lumb and Jones.,

Pondicherry, India: John Wiley & Sons; 2015;941-959.

2. Skarda R, Tranquilli W. Local and regional anesthetic and analgesic

techniques: ruminants and swine. In: Tranquilli WJ,

Thurmon JC, Grimm KA, editors. Lumb and Jones’ Veterinary

Anesthesia and Analgesia. 4th ed. Ames, IA: Blackwell

Publishing; 2007;643–681.

3. Iwamoto J, Yamagishi N, Sasaki K, Kim D, Devkota B, Furuhama

K. A novel technique of ultrasound-guided brachial plexus

block in calves. Res Vet Sci. 2012;93:1467-1471.

4. Moens Y. Brachial plexus block in goats using a nerve stimulator.

J Vet Anesth. 1995;22:39.

5. Estebe J-P, Le Corre P, Chevanne F, Cathelineau G, Le Verge

R, Ecoffey C. Motor blockade by brachial plexus block in the

sheep. Anesthesiology. 2000;93:291-293.

6. Estebe J-P, Le Corre P, Clement R, Du Plessis L, Chevanne F,

Le Verge R, et al. Effect of dexamethasone on motor brachial

plexus block with bupivacaine and with bupivacaine-loaded

microspheres in a sheep model. Eur J Anesthesiol.

2003;20:305-310.

7. Estebe J-P, Le Corre P, Du Plessis L, Chevanne F, Cathelineau

G, Le Verge R, et al. The pharmacokinetics and pharmacodynamics

of bupivacaine-loaded microspheres on a brachial

plexus block model in sheep. Anesth Analg. 2001;93:447-455.

8. Ghadirian S, Vesal N. Brachial plexus block using lidocaine/

epinephrine or lidocaine/xylazine in fat-tailed sheep. Vet Res

Forum. 2013;4:161-167.

9. Ghadirian S, Vesal N, Maghsoudi B, Akhlagh SH. Comparison

of lidocaine, lidocaine–morphine, lidocaine–tramadol or bupivacaine

for neural blockade of the brachial plexus in fattailed

lambs. Vet Anesth Analg. 2016;43:109-116.

10. McFarlane I. The lateral approach to pudendal nerve block in

the bovine and ovine. J S Afr Vet Assoc. 1963;34:73-76.

11. Garcia ER. Local Anesthetics. In: Grimm KA, Lamont LA,

Tranquilli WJ, Greene SA, Robertson SA, editors. Veterinary

Anesthesia and Analgesia, The Fifth Edition of Lumb and

Jones. John Wiley & Sons, Inc., Pondicherry, India; 2015;332-

354.

12. Sousa AM, Ashmawi HA. Local analgesic effect of tramadol is

not mediated by opioid receptors in early postoperative pain

in rats. Braz J Anesthesiol. (English Edition) 2015;65:186-190.

13. Tsai Y-C, Chang P-J, Jou I-M. Direct tramadol application on

sciatic nerve inhibits spinal somatosensory evoked potentials

in rats. Anesth Analg. 2001;92:1547-1551.

14. Baniadam A, Afshar FS, Ahmadian F. Analgesic effects of tramadol

hydrochloride administered via caudal epidural injection

in healthy adult cattle. Am J Vet Res. 2010;71:720-725.

15. Bigham A, Habibian S, Ghasemian F, Layeghi S. Caudal epidural

injection of lidocaine, tramadol, and lidocaine–tramadol

for epidural anesthesia in cattle. J vet pharmacol ther.

2010;33:439-443.

16. Dehkordi SH, Bigham-Sadegh A, Gerami R. Evaluation of anti-

nociceptive effect of epidural tramadol, tramadol-lidocaine

and lidocaine in goats. Vet Anesth Analg. 2012;39:106-110.

17. Habibian S, Bigham A, Aali E. Comparison of lidocaine, tramadol,

and lidocaine–tramadol for epidural analgesia in

lambs. Res Vet Sci. 2011;91:434-438.

18. Antonucci S. Adiuvants in the axillary brachial plexus blockade.

Comparison between clonidine, sufentanil and tramadol.

[Abstract] Minerva Anestesiol. 2000;67:23-27.

19. Geze Ş, Ulusoy H, Ertürk E, Cekic B, Arduc C. Comparison

of local anesthetic mixtures with tramadol

or fentanyl for axillary plexus

block in orthopaedic upper extremity

surgery. Eur J Gen Med. 2012;9:118-

123.

20. Kaabachi O, Ouezini R, Koubaa W,

Ghrab B, Zargouni A, Abdelaziz AB.

Tramadol as an adjuvant to lidocaine

for axillary brachial plexus block.

Anesth Analg. 2009;108:367-370.

21. Kapral S, Gollmann G, Waltl B, Likar R,

Sladen RN, Weinstabl C, et al. Tramadol

added to mepivacaine prolongs the

duration of an axillary brachial plexus

blockade. Anesth Analg. 1999;88:853-

856.

22. Nagpal V, Rana S, Singh J, Chaudhary

SK. Comparative study of systemically

and perineurally administered tramadol

as an adjunct for supraclavicular

brachial plexus block. J Anesthesiol,

Clin pharmacol. 2015;31:191.

23. Robaux S, Blunt C, Viel E, Cuvillon P,

Nouguier P, Dautel G, et al. Tramadol

added to 1.5% mepivacaine for axillary

brachial plexus block improves postoperative

analgesia dose-dependently.

Anesth Analg. 2004;98:1172-1177.

24. Sarsu S, Mizrak A, Karakurum G. Tramadol

use for axillary brachial plexus

blockade. J Surg Res. 2011;165:e23-e27.

25. Kayser V, Besson J-M, Guilbaud G. Evidence

for a noradrenergic component

in the antinociceptive effect of the analgesic

agent tramadol in an animal

model of clinical pain, the arthritic rat.

Eur J Pharmacol. 1992;224:83-88.

26. Haeseler G, Foadi N, Ahrens J, Dengler

R, Hecker H, Leuwer M. Tramadol,

fentanyl and sufentanil but not morphine

block voltage-operated sodium

channels. Pain. 2006;126:234-244.

27. Jou I-M, Chu K-S, Chen H-H, Chang

P-J, Tsai Y-C. The effects of intrathecal

tramadol on spinal somatosensory-

evoked potentials and motor-

evoked responses in rats. Anesth

Analg. 2003;96:783-788.

28. Mert T, Gunes Y, Gunay I. Local analgesic

efficacy of tramadol following intraplantar

injection. Eur J Pharmacol.

2007;558:68-72.

29. Wang JT, Chung CC, Whitehead RA,

Schwarz SKW, Ries CR, MacLeod BA.

Effects of local tramadol administration

on peripheral glutamate-induced

nociceptive behaviour in mice. Can J

Anesth. 2010;57:659-663.

30. Alemanno F, Ghisi D, Fanelli A, Faliva

A, Pergolotti B, Bizzarri F, Fanelli

G. Tramadol and 0.5% levobupivacaine

for single-shot interscalene

block: effects on postoperative analgesia

in patients undergoing shoulder

arthroplasty. Minerva Anestesiol.

2012;78:291-296.

31. Kesimci E, Izdes S, Gozdemir M, Kanbak

O. Tramadol does not prolong the

effect of ropivacaine 7.5 mg/ml for axillary

brachial plexus block. Acta anesthesiol

Scand. 2007;51:736-741.

32. Sakonju I, Maeda K, Maekawa R, Maebashi

R, Kakuta T, Takase K. Relative

nerve blocking properties of bupivacaine

and ropivacaine in dogs undergoing

brachial plexus block using

a nerve stimulator. J Vet Med Sci.

2009;71:1279-1284.

33. Futema F, Fantoni DT, Auler JOC,

Cortopassi SRG, Acaui A, Stopiglia

AJ. A new brachial plexus block technique

in dogs. Vet Anesth Analg.

2002;29:133-139.

34. Skarda R, Tranquilli W. Local anesthetics.

In: Tranquilli W, Thurmon J,

Grimm K, editors. Lumb and Jones’

Veterinary Anesthesia and Analgesia.

4th ed. Ames, IA: Blackwell Publishing;

2007;395–418.

35. Budd K. The role of tramadol in

acute pain management. Acute Pain.

1999;2:189-196.

36. Campoy L, Read MR. The Thoracic

Limb. In: Campoy L, Read MR, eds.

Small Animal Regional Anesthesia

and Analgesia. Pondicherry, India:

John Wiley & Sons; 2013;141-165.

37. Casati A, Danelli G, Baciarello M, Corradi

M, Leone S, Di Cianni S, et al. A

prospective, randomized comparison

between ultrasound and nerve stimulation

guidance for multiple injection

axillary brachial plexus block. Anesthesiology.

2007;106:992-996.

38. Schoenmakers KP, Wegener JT, Stienstra

R. Effect of local anesthetic volume

(15 vs 40 mL) on the duration of ultrasound-

guided single shot axillary brachial

plexus block: a prospective randomized,

observer-blinded trial. Reg

Anesth Pain Med. 2012;37:242-247.

39. Campoy L, Martin‐Flores M, Looney

AL, Erb HN, Ludders JW, Stewart JE,

Gleed RD, Asakawa M. Distribution

of a lidocaine‐methylene blue solution

staining in brachial plexus, lumbar

plexus and sciatic nerve blocks in the

dog. Vet Anesth Analg. 2008;35:348-

354.

40. Mahler SP, Adogwa AO. Anatomical

and experimental studies of brachial

plexus, sciatic, and femoral nerve‐location

using peripheral nerve stimulation

in the dog. Vet Anesth Analg.2008;35:80-89.