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Behrooz Fathi Fatemh Amani Atena Jami Al Ahmadi Abbase Zare

Abstract

Echis carinatus (Saw-scale viper) is one of the most venomous snakes in Asia and some
parts of the Africa with deadly hemotoxic venom. It has been reported that suramin, an antitrypansomiasis
drug, can inhibits the toxic effects of some snake venoms. This study was
conducted to evaluate the antagonistic effects of suramin against the venom of the Iranian
snake Echis carinatus.
Adult albino mice weighing 35±5g were divided into nine groups (A1, A2, B1, B2, B3, C1,
C2, D and E) of 6-10 mice. Groups A1 and A2 (protocol A), which received the venom at 7 and
13 mg/kg, succumbed after 169±32 min and 53±16 min, respectively. Groups B1, B2 and B3
(protocol B) were treated with different doses of suramin 15 min after injection of venom.
The results show that suramin significantly delayed time to death in groups B1, B2 and B3
compared with groups A1 and A2 (P<0.05). In groups C1 and C2 (Protocol C), venom was preincubated
with suramin for 15 min prior to injection into animals. The survival times of these
two groups were significantly increased when compared to group A2. Hhowever, only group
C1 in comparison with group A1 had a significantly increased survival time (P<0.05). Group D
(protocol D) was treated with suramin 15 min before injection of venom. Time to death in this
group increased in comparison to group A2. Group E received suramin alone as a control, and
all the animals in this group remained alive. The results of this study showed that a single
dose of suramin have a protective role against Echis carinatus venom at least in delaying time
to death of envenomed animals. Repeated administration or higher doses of suramin may be
able to prevent death caused by the venom

Article Details

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How to Cite
Behrooz, F., Fatemh, A., Atena, J. al ahmadi, & Abbase, Z. (2010). Antagonistic Effects of Suramin Against the Venom of the Iranian Snake Echis carinatus in Mice. Iranian Journal of Veterinary Science and Technology, 2(1), 9-16. https://doi.org/10.22067/veterinary.v2i1.3943
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Original Articles