Serum concentrations of lipids and lipoproteins and their correlations with thyroid hormones in clinically healthy German shepherd dogs: Effects of season, sex and age

Document Type : Research Articles

Authors

• Bahman Mosallanejad
• Ali Reza Ghadiri
• Reza Avizeh
• Mahdi Pourmahdi
• Marziae Rajabalipour

Shahid Chamran University of Ahvaz

10.22067/veterinary.v6i2.22722

Abstract

Although there are many evidences regard to the relationship between serum thyroid hormones, cholesterol, triglyceride and lipoproteins in different animals, but there are limited references in dogs. The aim of this study was to determine the correlation between thyroid hormones and concentrations of serum lipid and lipoprotein profiles, and also to detect relationship between the measured parameters in different season, sex and age groups of dogs in Ahvaz district, Southwest of Iran, on 2011. Blood samples were taken from the cephalic vein of 60 clinically healthy and non-pregnant native dogs in two seasons (summer and winter) and in two age groups (3 years). Sampling was done only once from each animal (30 dogs in every season). The serum concentrations of cholesterol, triglyceride (T.G), very low density lipoproteins (VLDL-cholesterol), low density lipoproteins (LDL-cholesterol), high density lipoproteins (HDL-cholesterol and their correlations with thyroxine (T4) and triiodothyronine (T3) hormones were measured in the studied dogs. The mean serum concentrations of cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol (mmol/L), T4 and T3 (µmol/L) were measured in the present survey. The above parameters were also obtained in two summer and winter seasons. Season had a significant effect on T.G, HDL, LDL and VLDL levels in the studied dogs (p0.05). No significant differences were detected for the measured cholesterol, T3 and T4 parameters in different age, sex and season groups (p>0.05). To the best of our knowledge, there was no previous research regarding the correlation of the thyroid hormones with the serum lipids and lipoproteins in dogs in Iran. Our results showed that thyroid hormones affect T.G, HDL, LDL and VLDL levels and observed seasonal change in serum may be partly due to changes in thyroid hormones.

Keywords

• thyroxine (T4)
• triiodothyronine (T3), lipid
• lipoprotein
• Dog
• Ahvaz

20.1001.1.2008465.2014.6.2.6.2

Main Subjects

• Clinical sciences

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References

Bertolucci, C., Fazio, F. and Piccione, G. (2008) Daily rhythms of serum lipids in dogs: influences of lighting and fasting cycles. Comparative Medicine 58, 485-489.

 

Bruss, M.L. (2008) Lipids and Ketones. In: Clinical Biochemistry Of Domestic Animals, 6th edn., Kaneko, J.J., Harvey, J.W. and Bruss, M.L. (Eds.). Academic Press Inc., New York, USA., ISBN: 13-978-0-12-370791-7, pp 81-116.

 

Campbell, K.L. and Davis, C.A. (1990) Effects of thyroid hormones on serum and cutaneous fatty acid concentrations in dogs. American Journal of Veterinary Research 51, 752-756.

Chatterjea, M.N. and Shinde, R. (2005) Textbook of medical biochemistry, 6th edn. Jaypee, New Delhi, pp 84-112.

 

Choi, S.Y., Hwang, J.S., Kim, I.H., Hwang, D.Y. and Kang, H.G. (2011) Basic data on the hematology, serum biochemistry, urology, and organ weights of beagle dogs. Laboratory Animal Research 27, 283-291.

 

Eshratkhah, B., Sadaghian, M., Khajeye, M., Ahmadi, H. and Mostafavi, H. (2008) Evaluation of non-electrolytes normal values in blood of Makuei sheep breed. Journal of Animal Veterinary and Advances 7, 327–329.

 

Ferm, K., Bjornefeldt, S., Karlsson, A., Andersson, G., Nachreiner, P, and Hedhammar, A. (2009) Prevalence of diagnostic characteristics indicating canine autoimmune lymphocytic thyroiditis in giant schnauzers and hovawart dogs. Journal of Small Animal Practice 50, 176-179.

 

Geffen, C., Bavegems, V., Duchateau, L., Roover, K. and Dainet, S. (2006) Serum thyroid hormone concentrations and thyroglobulin autoantibodies in trained and non-trained healthy whippets. The Veterinary Journal 172, 135-140.

 

Hill, R.C., Fox, L.E., Lewis, D.D., Beale, K.A., Nachreiner, R.E., Scott, K.C., Sundstrom, D.A., Jones, G.L, and Butterwick, R.F. (2001) Effects of racing and training on serum thyroid hormone concentrations in racing Greyhounds. The American Journal Veterinary Research 62, 1969-1972.

 

Huszenicza, G.y., Kulcsar, M. and Rudas, P. (2002) Clinical endocrinology of thyroid gland function in ruminant. Veterinary Medicine-Czech 47,199–210.

 

Kaciuba-Ubcilko, H., Greenleaf, J.E., Kozlowski, S., Brzeziska, Z., Nzar, K. and Ziemba, A. (1975) Thyroid hormone-induced changes in body temperature and metabolism during exercise in dogs. The American Journal of Physiology 229, 260-264.

 

Korhonen, H. (1987) Relationship between seasonal energy economy and thyroid activity in farm-raised raccoon dogs. Comparative Biochemistry and Physiology. A Comparative Physiology 87, 983-988.

 

Mazaki-Tovi, M., Feuermann, Y., Segev, G., Klement, E., Yas-Natan, E., Farkas, A., Kol, A. and Shamay, A. (2010) Increased serum leptin and insulin concentrations in canine hypothyroidism. Veterinary Journal 183, 109-114.

 

Nazifi, S., Gheisari, H.R., Abbasali Poorkabir, M. and Saadatfar, S. (2000) Serum lipids and lipoproteins in clinically healthy male camels (Camelusdromedarius). Veterinary Research Communications 24, 524–531.

 

Nazifi, S., Saeb, M., Rowghani, E., Hasankhani, M., Hasankhani, F. and Ghafari, N. (2007) Studies on the relationship between thyroid hormones, serum lipid profile and erythrocyte antioxidant enzymes in clinically healthy Iranian fat-tailed sheep. Bulgarian Journal of Veterinary Medicine 10, 161-167.

 

Oohashi, E., Yagi, K., Uzuka, Y., Tanabe, S., Sharashina, T, and Ishida, T. (2001) Seasonal changes in serum total thyroxine, free thyroxine and canine thyroid response hormone in clinically healthy beagles in Hokkaido. Journal of Veterinary Medical Sciences 63, 1241-1243.

 

Pena, C., Suarez, L., Bautista, I., Montoya, J.A. and Juste, M.C. (2008) Relationship between analytic values and canine obesity. Journal of Animal Physiology and Animal Nutrition 92, 324-325.

 

Saicic, Z.S., Mijalovic, D.N., Nikolic, A.L. and Blagojevic, S.M.B. (2006) Effect of thyroxine on antioxidant defense system in the liver of rats of different age. Physiology Research 55, 561–568.

Todini, L. (2007) Thyroid hormones in small ruminants: effects of endogenous, environmental and nutritional factors. Journal of Animal Sciences 1, 997-1008.

 

Tuckova, M., Fialkovicova, M., Baranova, D., Bekeova, E., Kozak, M. and Paleni k, L. (1995) Seasonal effect on serum levels of thyroid hormones in German shepherds and dachshunds and their health status. Veterinary Medicine 40, 249-252.

 

Verkest, K.R., Fleeman, L.M., Morton, J.M., Groen, S.J., Suchodolski, J.S., Steiner, J.M. and Rand, J.S. (2012) Association of postprandial serum triglyceride concentration and serum canine pancreatic lipase immunoreactivity in overweight and obese dogs. Journal of Veterinary Internal Medicine 26, 46-53.

 

Wolford, S.T., Schroer, R.A., Gohs, F.X., Gallo, P.P., Falk, H.B. and Dente, A.R. (1988) Effect of age on serum chemistry profile, electrophoresis and thyroid hormones in beagle dogs two weeks to one year of age. Veterinary Clinical Pathology 17, 35-42.

 

Yalcin, E., Icol, Y.O. and Batmaz, H. (2009) Serum lipid concentrations in dogs with tail chasing. The Journal of Small Animal Practice 50, 133-135.