Serum biochemical and oxidative status in Holstein cattle affected with foot and mouth disease

Document Type : Research Articles

Authors

1 Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.

2 Department of Pathobiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.

Abstract

Foot and mouth disease (FMD) is a severe, highly contagious viral disease of cloven-hoofed ruminants caused by an aphthovirus of the family Picornaviridae. The disease in cattle is clinically characterized by fever and vesicles on the foot, in the oral cavity and on the mammary gland.This study was carried out to determine the changes in some serum biochemical parameters of cattle naturally infected with FMD O in Shahrekord district, Iran. For this purpose, blood samples were obtained from 23 Holsteins with clinical signs of FMD, as well as 22 blood samples from healthy animals. Serum analysis revealed significantly higher levels of AST, CK, CK-MB and LDH activities as well as MDA, troponin I, glucose and triglycerides concentrations in FMD-affected cattle compared to healthy control group (p < 0.05). Serum GPx and SOD activities in cattle with FMD were significantly lower than those in normal animals (p < 0.05), while there was no significant difference in serum CAT activity between 2 groups of animals. It is concluded that oxidative stress and some degrees of myocardial and pancreatic lesions develop in FMD-affected cattle. These findings provided information to better understand the pathogenesis of the disease and gives further insight to improve supportive treatment procedures in FMD virus infection in cattle.

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References

1. Constable PD, Hinchcliff KW, Done SH, et al.Veterinary Medicine, A Textbook of Diseases of Cattle, Horses. Sheep, Pigs and Goats. 11 ed. St. Louis: Elsevier, 2017;pp.
2. Poonsuk K, Gimenez-Lirola L, Zimmerman JJ. A review of foot-and-mouth disease virus (FMDV) testing in livestock with an emphasis on the use of alternative diagnostic specimens. Animal health research reviews 2018;19:100-112.
3. Admassu B, Getnet K, Shite A, et al. Review on foot and mouth disease: Distribution and economic significance. Academic Journal of Animal Diseases 2015;4:160-169.
4. Arzt J, Juleff N, Zhang Z, et al. The pathogenesis of foot‐and‐mouth disease I: viral pathways in cattle. Transboundary and emerging diseases 2011;58:291-304.
5. Stenfeldt C, Segundo D-S, de los Santos T, et al. The pathogenesis of foot-and-mouth disease in pigs. Frontiers in veterinary science 2016;3:41.
6. Arzt J, Baxt B, Grubman M, et al. The Pathogenesis of Foot‐and‐Mouth Disease II: Viral Pathways in Swine, Small Ruminants, and Wildlife; Myotropism, Chronic Syndromes, and Molecular Virus–Host Interactions. Transboundary and emerging diseases 2011;58:305-326.
7. Khoshvaghti A, Askari A, Nazifi S, et al. Evaluation of some antioxidant enzymes in cattle infected with foot and mouth virus. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 2014;40:70-75.
8. Ryan E, Horsington J, Durand S, et al. Foot-and-mouth disease virus infection in young lambs: pathogenesis and tissue tropism. Veterinary microbiology 2008;127:258-274.
9. Aslani MR, Mohri M, Movassaghi AR. Serum troponin I as an indicator of myocarditis in lambs affected with foot and mouth disease. Veterinary research forum: an international quarterly journal 2013;59.
10. Sobhy NM, Bayoumi YH, Mor SK, et al. Outbreaks of foot and mouth disease in Egypt: Molecular epidemiology, evolution and cardiac biomarkers prognostic significance. International journal of veterinary science and medicine 2018;6:22-30.
11. Weber J, Zenker M, Köller G, et al. Clinical chemistry investigations in recumbent and healthy German Holstein cows after the fifth day in milk. Journal of Veterinary Research 2019.
12. Hoffmann WE, Solter PF. Clinical biochemistry of domestic animals In: Kaneko JJ, Harvey JW,Bruss ML, eds. 6 ed: Academic press, 2008;pp.
13. Burns L, Ramos A, Veiga A, et al. Evaluation of muscle tissue and liver glycogen of cattle submitted to transport over long distances and subjected to emergency slaughter. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia 2019;71:1067-1075.
14. EL-DEEN NAN, NEAMAT-ALLAH AN, RIZK LG, et al. Serological, hematological, biochemical and oxidative markers during foot and mouth disease serotype ‘O’infection, Egypt. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Veterinary Medicine 2017;74:218-226.
15. Singh Z, Karthigesu IP, Singh P, et al. Use of malondialdehyde as a biomarker for assessing oxidative stress in different disease pathologies: a review. Iranian Journal of Public Health 2014;43:7-16.
16. Ighodaro O, Akinloye O. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria Journal of Medicine 2018;54:287-293.
17. Strycharz-Dudziak M, Kiełczykowska M, Drop B, et al. Total Antioxidant Status (TAS), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) in Oropharyngeal Cancer Associated with EBV Infection. Oxidative medicine and cellular longevity 2019;2019.
18. Ye S, Lowther S, Stambas J. Inhibition of reactive oxygen species production ameliorates inflammation induced by influenza A viruses via upregulation of SOCS1 and SOCS3. Journal of virology 2015;89:2672-2683.
19. Zendehbad B, Alipour A, Zendehbad H. Effect of tetracycline administration on serum amylase activity in calves. SpringerPlus 2013;2:330.
20. Barker I, Van Dreumel A. Foot-and-mouth disease In: Jubb KVF, Kennedy PC,Palmer N, eds. Pathology of Domestic Animals: Academic Press, San Diego, 1992;pp: 141–144.
21. Berkowitz A, Waner T, King R, et al. Description of the pathology of a gazelle that died during a major outbreak of foot-and-mouth disease in Israel: clinical communication. Journal of the South African Veterinary Association 2012.
22. Habiela M, Seago J, Perez-Martin E, et al. Laboratory animal models to study foot-and-mouth disease: a review with emphasis on natural and vaccine-induced immunity. The Journal of general virology 2014;95:2329.
23. Buege JA, Aust SD. [30] Microsomal lipid peroxidation. Methods in enzymology: Elsevier, 1978;pp: 302-310.
24. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clinical chemistry 1988;34:497-500.
25. Goth L. A simple method for determination of serum catalase activity and revision of reference range. Clinica chimica acta 1991;196:143-151.
26. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The Journal of laboratory and clinical medicine 1967;70:158-169.
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History

  • Receive Date: 15 January 2020
  • Revise Date: 16 February 2020
  • Accept Date: 05 May 2020

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