Effect of four local anesthetics (tetracaine, bupivacaine, lidocaine and proparacaine) on intraocular pressure in rabbits- Comparison of an applanation and a rebound tonometer

Document Type : Research Articles

Authors

Ferdowsi University of Mashhad

Abstract

The type of device used, the type of local anesthetic agents, and the animal species may affect the intraocular pressure(IOP). Therefore, in order to determine these issues, the effects of four local anesthetics were investigated in 10 adult rabbits by ICare TA01i and Tono-Pen Vet tonometers. In the right eye of half of the rabbits and in the left eye of the other half of the rabbits, one drop of tetracaine was instilled. The IOP in each rabbit was measured using two tonometers, ICare and Tono-Pen Vet, before and each 5 minutes until 40 minutes later. The effects of other drugs were also studied at least with one-week interval. Based on the results of ICare tonometer, tetracaine significantly reduced the IOP immediately and 25 minutes after instillation. IOP changes after instillation of bupivacaine, lidocaine and proparacaine were not significant at any time compared to baseline values (p > 0.05). Based on the results of Tono-Pen Vet tonometer, all drugs reduced the IOP immediately after use; however, the effects of bupivacaine and lidocaine on IOP were much lower than that of tetracaine and proparacaine. The average duration of corneal anesthesia were 20, 15.5, 7.5 and 21 minutes for tetracaine, bupivacaine, lidocaine, and proparacaine, respectively. It is concluded that IOP reduction by local anesthetics when Tono-Pen Vet is used is much greater than the ICare tonometer measurements. Also, the reduction of IOP with each of the devices when tetracaine or proparacaine is used is greater than when bupivacaine or lidocaine is used.

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References

1. Plummer CE, Regnier A, Gelatt KN. The Canine Glaucomas. In: Gelatt KN, Gilger BC, Kern TJ, editors. Vet Ophthalmol. 2: John Wiley & Sons; 2013. p. 1050-145.
2. Gofman N, Cohen B, Matot I, Cattan A, Dotan G, Stolovitch C, et al. Do intraocular pressure measurements under anesthesia reflect the awake condition? J Glaucoma. 2017;26(4):299-302.
3. Prabhakar S, Mahesh B, Shanthamallappa M. A comparative study of intraocular pressure measurement by three tonometers in normal subjects. Nepal J Ophthalmol. 2013;5(2):201-6.
4. Baudouin C, Gastaud P. Influence of topical anesthesia on tonometric values of intraocular pressure. Ophthalmologica. 1994;208(6):309-13.
5. Boillot T, Gauvin M, Rosolen S-G. Effect of topical application of tetracaine on intraocular pressure in dogs: preliminary results. J Fr Ophtalmol. 2013;36(5):402-7.
6. Johannesson G, Hallberg P, Eklund A, Behndig A, Linden C. Effects of topical anaesthetics and repeated tonometry on intraocular pressure. Acta Ophthalmol (Copenh). 2014;92(2):111-5.
7. Montero J, Ruiz-Moreno J, Fernandez-Munoz M, Rodriguez-Palacios M. Effect of topical anesthetics on intraocular pressure and pachymetry. Eur J Ophthalmol. 2008;18(5):748-50.
8. Sarchahi AA, Bozorgi H. Effect of tetracaine on intraocular pressure in normal and hypertensive rabbit eyes. J Ophthalmic Vis Res. 2012;7(1):29-33.
9. Ehongo A, De Maertelaer V, Pourjavan S. Effect of topical corneal anaesthesia on ocular response analyzer parameters: pilot study. Int Ophthalmol. 2009;29(5):325-8.
10. Kim J, Kim NS, Lee KC, Lee HB, Kim MS, Kim HS. Effect of topical anesthesia on evaluation of corneal sensitivity and intraocular pressure in rats and dogs. Vet Ophthalmol. 2013;16(1):43-6.
11. Parchen H, Izar M, Branco P, Lacowicz C, Sano D, Belo C, et al. Ophthalmic and anesthetic evaluation of topical 1% tetracaine and 0.5% proparacaine in dogs. Arq Bras Med Vet Zootec. 2011;63(6):1337-44.
12. Murgatroyd H, Bembridge J. Intraocular pressure. Continuing Education in Anaesthesia Critical Care & Pain. 2008;8(3):100-3.
13. Ogbuehi KC. Corneal biomechanical parameters and intraocular pressure: the effect of topical anesthesia. Clin Ophthalmol. 2012;6:871.
14. Sarchahi AA, Eskandari M. Effect of four local anesthetics (tetracaine, proparacaine, lidocaine, and bupivacaine) on intraocular pressure in dogs. Int Ophthalmol. 2019;39(7):1467-74.
15. Knollinger AM, La Croix NC, Barrett PM, Miller PE. Evaluation of a rebound tonometer for measuring intraocular pressure in dogs and horses. J Am Vet Med Assoc. 2005;227(2):244-8.
16. Leiva M, Naranjo C, Pena M. Comparison of the rebound tonometer (ICare®) to the applanation tonometer (Tonopen XL®) in normotensive dogs. Vet Ophthalmol. 2006;9(1):17-21.
17. Wang X, Dong J, Wu Q. Twenty‐four‐hour measurement of IOP in rabbits using rebound tonometer. Vet Ophthalmol. 2013;16(6):423-8.
18. Nociti J, Serzedo P, Zuccolotto E, Nunes A, Ferreira S. Intraocular pressure and ropivacaine in peribulbar block: a comparative study with bupivacaine. Acta Anaesthesiol Scand. 2001;45(5):600-2.
19. Abdulla W, Flaifil H. Intraocular pressure changes in response to endotracheal intubation facilitated by atracurium or succinylcholine with or without lidocaine. Acta Anaesthesiol Belg. 1992;43(2):91-101.
20. Lerman J, Kiskis AA. Lidocaine attenuates the intraocular pressure response to rapid intubation in children. Can Anaesth Soc J. 1985;32(4):339-45.
21. Hassanein A, Zekry J, Moharram H. Effect of lidocaine instillation into endotracheal tube on intraocular pressure during extubation. Ain-Shams J Anaesthesiol. 2016;9(1):23-6.
22. Dosunmu EO, Marcus I, Tung I, Thiamthat W, Freedman SF. The effect of repeated measurements and the use of topical anesthetic on rebound tonometry values in children. J AAPOS. 2014;18(6):619-21.
23. Herse P, Siu A. Short‐term effects of proparacaine on human corneal thickness. Acta Ophthalmol (Copenh). 1992;70(6):740-4.
24. Ko Y, Liu C-l, Hsu W. Varying effects of corneal thickness on intraocular pressure measurements with different tonometers. Eye. 2005;19(3):327-32.
25. Nam SM, Lee HK, Kim EK, Seo KY. Comparison of corneal thickness after the instillation of topical anesthetics: proparacaine versus oxybuprocaine. Cornea. 2006;25(1):51-4.
26. Bartfield JM, Holmes TJ, Raccio‐Robak N. A comparison of proparacaine and tetracaine eye anesthetics. Acad Emerg Med. 1994;1(4):364-7.
27. Gum GG, MacKay EO. Physiology of the Eye. In: Gelatt KN, Gilger BC, Kern TJ, editors. Vet Ophthalmol. 1: John Wiley & Sons; 2013. p. 170-207.
28. Sun R, Hamilton RC, Gimbel HV. Comparison of 4 topical anesthetic agents for effect and corneal toxicity in rabbits. J Cataract Refract Surg. 1999;25(9):1232-6.
29. Liu JC, Steinemann TL, McDonald MB, Thompson HW, Beuerman RW. Topical bupivacaine and proparacaine: a comparison of toxicity, onset of action, and duration of action. Cornea. 1993;12(3):228-32.
30. Assia EI, Pras E, Yehezkel M, Rotenstreich Y, Jager-Roshu S. Topical anesthesia using lidocaine gel for cataract surgery. J Cataract Refract Surg. 1999;25(5):635-9.
31. Shah H, Reichel E, Busbee B. A novel lidocaine hydrochloride ophthalmic gel for topical ocular anesthesia. Local Reg Anesth. 2010;3:57-63.
32. Binder DR, Herring IP. Duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in clinically normal cats. Am J Vet Res. 2006;67(10):1780-2.
33. Herring IP, Bobofchak MA, Landry MP, Ward DL. Duration of effect and effect of multiple doses of topical ophthalmic 0.5% proparacaine hydrochloride in clinically normal dogs. Am J Vet Res. 2005;66(1):77-80.
34. Kalf KL, Utter ME, Wotman KL. Evaluation of duration of corneal anesthesia induced with ophthalmic 0.5% proparacaine hydrochloride by use of a Cochet-Bonnet aesthesiometer in clinically normal horses. Am J Vet Res. 2008;69(12):1655-8.
35. Parr A, Zoutman D, Davidson J. Antimicrobial activity of lidocaine against bacteria associated with nosocomial wound infection. Ann Plast Surg. 1999;43(3):239-45.
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  • Receive Date: 31 August 2019
  • Accept Date: 29 February 2020

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