Interactive effects of peripheral and central administration of LPS with inhibition of CRF receptors on food intake in neonatal chicks

Document Type : Research Articles

Authors

shahid bahonar university

Abstract

Anorexia is a part of the acute phase response (APR). Lipopolysaccharide (LPS) is frequently used to mimic APR and induces anorexia. The mechanism underlying anorexia associated with APR in chicks is not well understood. In the present study, the possible involvement of corticotrophin-releasing factor (CRF) on anorexic effects of LPS in neonatal chicks was investigated. For this aim, different doses of LPS were administrated via both intracerebroventricular (ICV) and intraperitoneal (IP) routes in order to assess its effects on chick’s food intake. Subsequently, the effect of ICV injection of astressin, a CRF receptor antagonist, on anorexia induced by ICV and IP administration of LPS was investigated. Food intake was significantly decreased following either central or systemic administration of LPS. ICV co -injection of astressin and LPS significantly diminished anorexic effects of central LPS. However, anorexia induced by peripheral LPS was not attenuated by central injection of astressin. These data indicated that the brain CRF receptors are involved in central LPS-induced anorexia in chicks.

Keywords

Main Subjects

References

1. Denbow DM, Cline MA. Food intake regulation. Sturkie’s Avian Physiology (Sixth Edition): Elsevier; 2015. p. 469-85.
2. Utoyama M, Akieda-Asai S, Koda S, Nunoi H, Date Y. Role of the neural pathway from hindbrain to hypothalamus in the regulation of energy homeostasis in rats. Neuroscience letters. 2016;614:83-8.
3. Tachibana T, Tsutsui K. Neuropeptide Control of Feeding Behavior in Birds and Its Difference with Mammals. Frontiers in Neuroscience. 2016;10.
4. Becskei C, Riediger T, Hernadfalvy N, Arsenijevic D, Lutz TA, Langhans W. Inhibitory effects of lipopolysaccharide on hypothalamic nuclei implicated in the control of food intake. Brain, behavior, and immunity. 2008;22(1):56-64.
5. Pecchi E, Dallaporta M, Jean A, Thirion S, Troadec J-D. Prostaglandins and sickness behavior: old story, new insights. Physiology & behavior. 2009;97(3):279-92.
6. Baumann H, Gauldie J. The acute phase response. Immunology today. 1994;15(2):74-80.
7. Cray C, Zaias J, Altman NH. Acute phase response in animals: a review. Comparative medicine. 2009;59(6):517-26.
8. Weiland TJ, Anthony-Harvey-Beavis D, Voudouris NJ, Kent S. Metabotropic glutamate receptors mediate lipopolysaccharide-induced fever and sickness behavior. Brain, behavior, and immunity. 2006;20(3):233-45.
9. Verdrengh M, Tarkowski A. Role of neutrophils in experimental septicemia and septic arthritis induced by Staphylococcus aureus. Infection and immunity. 1997;65(7):2517-21.
10. Kakucska I, Qi Y, Clark B, Lechan R. Endotoxin-induced corticotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin-1. Endocrinology. 1993;133(2):815-21.
11. Durairaj H, Steury MD, Parameswaran N. Paroxetine differentially modulates LPS-induced TNFα and IL-6 production in mouse macrophages. International immunopharmacology. 2015;25(2):485-92.
12. Vale W, Spiess J, Rivier C, Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin. Science. 1981:1394-7.
13. Dunn AJ, Berridge CW. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain research reviews. 1990;15(2):71-100.
14. Chalmers DT, Lovenberg TW, De Souza EB. Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression. Journal of Neuroscience. 1995;15(10):6340-50.
15. Lowry P, Kemp C, Woods R. Corticotropin Releasing Factor-Binding Protein. Stress Science: Neuroendocrinology. 2010:112.
16. Yeh C, Ting C-H, Doong M-L, Chi C-W, Lee S-D, Chen C-Y. Intracerebroventricular urocortin 3 counteracts central acyl ghrelin-induced hyperphagic and gastroprokinetic effects via CRF receptor 2 in rats. Drug Design, Development and Therapy. 2016;10:3281.
17. Zhang R, Nakanishi T, Ohgushi A, Ando R, Yoshimatsu T, Denbow DM, et al. Suppression of food intake induced by corticotropin-releasing factor family in neonatal chicks. European journal of pharmacology. 2001;427(1):37-41.
18. Denbow DM, Snapir N, Furuse M. Inhibition of food intake by CRF in chickens. Physiology & behavior. 1999;66(4):645-9.
19. Saito E-S, Kaiya H, Tachibana T, Tomonaga S, Denbow DM, Kangawa K, et al. Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regulatory peptides. 2005;125(1-3):201-8.
20. Langhans W, Balkowski G, Savoldelli D. Differential feeding responses to bacterial lipopolysaccharide and muramyl dipeptide. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1991;261(3):R659-R64.
21. Beutler B, Greenwald D, Hulmes J, Chang M, Pan Y-C, Mathison J, et al. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. 1985;316(6028):552.
22. Dinarello CAJB. Biologic basis for interleukin-1 in disease. 1996;87(6):2095-147.
23. Marinkovic S, Jahreis GP, Wong GG, Baumann HJTJoI. IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo. 1989;142(3):808-12.
24. Hua J, Qiu DK, Li JQ, Li EL, Chen XY, Peng YSJJog, et al. Expression of Toll‐like receptor 4 in rat liver during the course of carbon tetrachloride‐induced liver injury. 2007;22(6):862-9.
25. Miller SB, editor Prostaglandins in health and disease: an overview. Seminars in arthritis and rheumatism; 2006: Elsevier.
26. Johnson R, Curtis S, Dantzer R, Bahr J, Kelley K. Sickness behavior in birds caused by peripheral or central injection of endotoxin. Physiology & behavior. 1993;53(2):343-8.
27. Johnson R, Curtis S, Dantzer R, Kelley KW. Central and peripheral prostaglandins are involved in sickness behavior in birds. Physiology & behavior. 1993;53(1):127-31.
28. De Boever S. Characterization of an intravenous LPS inflammation model in broilers with respect to the pharmacokinetics and pharmacodynamics of nonsteroidal anti-inflammatory drugs: Ghent University; 2009.
29. Macari M, Furlan R, Gregorut F, Secato E, Guerreiro J. Effects of endotoxin, interleukin‐1/3 and prostaglandin injections on fever response in broilers. British poultry science. 1993;34(5):1035-42.
30. KLASING KC. Avian leukocytic cytokines. Poultry science. 1994;73(7):1035-43.
31. Xie H, Rath N, Huff G, Huff W, Balog J. Effects of Salmonella typhimurium lipopolysaccharide on broiler chickens. Poultry Science. 2000;79(1):33-40.
32. Nieuwenhuizen AG, Rutters F. The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance. Physiology & behavior. 2008;94(2):169-77.
33. Tachibana T, Sato M, Oikawa D, Furuse M. Involvement of CRF on the anorexic effect of GLP-1 in layer chicks. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 2006;143(1):112-7.
34. Tachibana T, Matsuda K, Kawamura M, Ueda H, Khan MSI, Cline MA. Feeding-suppressive mechanism of sulfated cholecystokinin (26–33) in chicks. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 2012;161(4):372-8.
35. Tachibana T, Saito E-S, Takahashi H, Saito S, Tomonaga S, Boswell T, et al. Anorexigenic effects of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide in the chick brain are mediated by corticotrophin-releasing factor. Regulatory peptides. 2004;120(1-3):99-105.
36. Honda K, Kamisoyama H, Uemura T, Yanagi T, Saito N, Kurose Y, et al. The mechanism underlying the central glucagon-induced hyperglycemia and anorexia in chicks. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 2012;163(3-4):260-4.
37. Uehara Y, Shimizu H, Ohtani K-i, Sato N, Mori MJD. Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin. Diabetes. 1998;47(6):890.
38. Lacroix S, Vallières L, Rivest SJJon. C-fos mRNA pattern and corticotropin-releasing factor neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type. Journal of Neuroimmunology.1996;70(2):163-79.
39. Oka T, Oka K, Scammell TE, Lee C, Kelly JF, Nantel F, et al. Relationship of EP1‐4 prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses. Journal of comparative neurology. 2000;428(1):20-32.
40. Vallières L, Rivest SJE. Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia. Endocrinology.1999;140(9):3890-903.
41. Cao C, Matsumura K, Yamagata K, Watanabe YJBr. Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever. Brain research. 1996;733(2):263-72.
42. Laflamme N, Lacroix S, Rivest SJJoN. An essential role of interleukin-1β in mediating NF-κB activity and COX-2 transcription in cells of the blood–brain barrier in response to a systemic and localized inflammation but not during endotoxemia. The Journal of Neuroscience. 1999;19(24):10923-30.
43. Rivest S. What is the cellular source of prostaglandins in the brain in response to systemic inflammation? Facts and controversies. Nature Publishing Group; 1999.
44. Zhang J, Rivest SJEJoN. Distribution, regulation and colocalization of the genes encoding the EP2‐and EP4‐PGE2 receptors in the rat brain and neuronal responses to systemic inflammation. The european journal of neuroscience. 1999;11(8):2651-68.
45. Nakamura K, Li Y-Q, Kaneko T, Katoh H, Negishi M. Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: a double immunofluorescence study in the rat brain. Neuroscience. 2001;103(3):763-75.
46. Wylie CJ, Hendricks TJ, Zhang B, Wang L, Lu P, Leahy P, et al. Distinct transcriptomes define rostral and caudal serotonin neurons. Journal of Neuroscience. 2010;30(2):670-84.
47. Asarian L, Kopf B, Hrupka B, Geary N, Langhans W. Evidence that LPS elicits anorexia via PGE2 signaling in the midbrain raphe. Appetite. 2009;52(3):817.
48. Asarian L, Langhans WJP, behavior. A new look on brain mechanisms of acute illness anorexia. Physiology and behavior. 2010;100(5):464-71.
49. Zendehdel M, Taati M, Jonaidi H, Amini. The role of central 5-HT 2C and NMDA receptors on LPS-induced feeding behavior in chickens. Journal of Physiological Sciences 2012;62(5):413-9.
50. Davis JL, Masuoka DT, Gerbrandt LK, Cherkin A. Autoradiographic distribution of L-proline in chicks after intracerebral injection. Physiology & Behavior. 1979;22(4):693-5.
51. Zendehdel M, Mokhtarpouriani K, Hamidi F, Montazeri R. Intracerebroventricular injection of ghrelin produces hypophagia through central serotonergic mechanisms in chicken. Veterinary research communications. 2013;37(1):37-41.
Send comment about this article
CAPTCHA Image

Files

History

  • Receive Date: 08 November 2018
  • Revise Date: 06 May 2019
  • Accept Date: 22 May 2019

Share

How to cite

Statistics