TY - JOUR ID - 42835 TI - Modulatory roles of ergothioneine on heat shock protein-70, tumour necrosis factor-alpha, and rectal temperatures of Arabian stallions following race of 2000 m in a hot-dry environment JO - Iranian Journal of Veterinary Science and Technology JA - IJVST LA - en SN - 2008-465X AU - Adah, Adakole AU - Ayo, Joseph AU - Rekwot, Peter AU - Aluwong, Tagang AU - Adah, Deborah AD - Department of Veterinary Physiology and Biochemistry, University of Ilorin, P. M. B. 1515, Ilorin, Nigeria. AD - Department of Veterinary Physiology, Ahmadu Bello University, P. M. B. 1044, Samaru- Zaria, Nigeria. AD - National Animal Production Research Institute, P. M. B. 1096, Shika-Zaria, Nigeria. AD - Department of Veterinary Medicine, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria. Y1 - 2022 PY - 2022 VL - 14 IS - 4 SP - 19 EP - 25 KW - Ergothioneine KW - Hot-Dry Season KW - tumor necrosis factor-α KW - Heat shock protein-70 KW - Rectal temperature DO - 10.22067/ijvst.2022.76793.1150 N2 - Experiments were performed to determine the effect of ergothioneine on rectal temperature and the serum concentrations of heat shock protein-70 (HSP-70) and tumor necrosis factor-α (TNF-α) in stallions following a race of 2000 m in a hot-dry environment. Eighteen stallions weighing approximately 400 kg each were used for the experiment. They were divided into three groups of six stallions each. Group I (EEX) was the experimental group that was administered ergothioneine (0.5 mg/kg per os), while group II (EEC) did not receive ergothioneine before exercise. The third group (EEN) was neither administered ergothioneine nor exercised. The dry-bulb temperature and the relative humidity of the experiment were determined for six days and on the day of the experiment. The temperature-humidity index was also calculated. Rectal temperature, serum HSP-70, and TNF-α concentrations of all horses were measured before commencement, immediately after, and 2 h after the exercise. The dry-bulb temperature and relative humidity which showed diurnal fluctuations increased significantly (p < 0.05) between 06.00 h and 12.00 h (22.6 ± 1.23 and 38.6 ± 6.5, respectively). Serum TNF-α and HSP-70 levels of the stallions in the EEX group were higher than the values obtained in the EEC and EEN groups (p < 0.05). The values of rectal temperature obtained were lower (p < 0.05) in the EEX group than in the other groups. Therefore, it could be concluded that ergothioneine modulated rectal temperature, as well as TNF-α and HSP-70 concentrations in the stallions, and might be beneficial to horses during exercise. UR - https://ijvst.um.ac.ir/article_42835.html L1 - https://ijvst.um.ac.ir/article_42835_0a1538bc5ef6b66d12d1b0099f9a473d.pdf ER -