Document Type : Research Article
Authors
1
Department of Veterinary Clinical Sciences, Karaj branch, Islamic Azad University, Karaj, Iran
2
Department of Pharmacology, Karaj branch, Islamic Azad University, Karaj, Iran
3
Department of radiology, Karaj branch, Islamic Azad University, Karaj, Iran
4
Department of Surgery and Radiology, Faculty of veterinary medicine, University of Tehran, Tehran, Iran
10.22067/ijvst.2024.82405.1250
Abstract
keeping rabbits as pets and their use in laboratory research increased the need for research into heart disease and treatment in rabbits. Pimobendan is one of the most common drugs which is used in cardiac diseases. Its use in rabbits is anecdotal. The first step toward the approval of pimobendan in rabbits is the potential for beneficial effects on cardiac function. It can be detected by echocardiographic functional parameters. This study aimed to determine the pimobendan’s effects on echocardiographic parameters. Eleven rabbits were included in this study. Echocardiographic examinations were done before and after pimobendan administration for each rabbit. LV morphological and functional parameters were compared between time points. pimobendan resulted in changes in several echocardiographic variables in rabbits; Specifically, FS, EF, SV, LVPWs, and LA end-systolic increased (p=0.0001, p=0.0001, p=0.0284, p=0.0272, and p=0.0007, respectively), whereas LVIDs and ESV decreased (p=0.0343 and p=0.038). It wasn’t a meaningful change in some parameters like LVIDd, LVPWd, EDV, LA max, Mitral annulus diameter, and LA/Ao. This study showed positive effects on function and improve cardiac function in healthy rabbits after oral administration of pimobendan. Further studies are required to investigate whether pimobendan has similar effects in rabbits with cardiac disease.
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